FAP CHO
CBP74255
| I. Background | |
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FAP (Fibroblast Activation Protein Alpha) is a Protein Coding gene. Diseases associated with FAP include Familial Adenomatous Polyposis 1 and Melanoma. Among its related pathways is T cell modulation in pancreatic cancer. |
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| II. Description | |
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The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. |
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| III. Introduction | |
| Expressed gene: | FAP |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| IV. Representative Data | |
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Figure 1. Recombinant FAP CHO constitutively expressing FAP. |
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